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Consumers may regard certain cultivars as "premium" quality. The "Aquila" saffron, or zafferano dell'Aquila, is defined by high safranal and crocin content, distinctive thread shape, unusually pungent aroma, and intense colour; it is grown exclusively on eight hectares in the Navelli Valley of Italy's Abruzzo region, near L'Aquila. It was first introduced to Italy by a Dominican friar from inquisition-era Spain. [ when?] But the biggest saffron cultivation in Italy is in San Gavino Monreale, Sardinia, where it is grown on 40 hectares, representing 60% of Italian production; it too has unusually high crocin, picrocrocin, and safranal content. Willard, P. (2002), Secrets of Saffron: The Vagabond Life of the World's Most Seductive Spice, Beacon Press, ISBN 978-0-8070-5009-5 that is, or may reasonably be considered to be submitted in extreme volumes and as such be deemed as ‘spam’; Fotedar, S. (1999). "Cultural Heritage of India: The Kashmiri Pandit Contribution". Vitasta. Kashmir Sabha of Kolkata. 32 (1): 128. Archived from the original on 29 September 2011 . Retrieved 15 September 2011. Main article: History of saffron A detail from the "Saffron Gatherers" fresco of the "Xeste 3" building. It is one of many depicting saffron; they were found at the Bronze Age settlement of Akrotiri, on the Aegean island of Santorini.
Dharmananda, S. (2005), "Saffron: An Anti-Depressant Herb", Institute for Traditional Medicine, archived from the original on 26 September 2006 , retrieved 10 January 2006 Francis, S. (2011), Saffron: The Story of England's Red Gold, With Delicious Saffron Recipes that Family and Friends will Love, Norfolk Saffron, ISBN 978-0-955-04667-4 Abdullaev, F. I. (2002), "Cancer Chemopreventive and Tumoricidal Properties of Saffron ( Crocus sativus L.)", Experimental Biology and Medicine, vol.227, no.1, pp.20–5, doi: 10.1177/153537020222700104, PMID 11788779, S2CID 40798771, archived from the original on 3 December 2008 , retrieved 11 September 2011
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Dai, Lili; Chen, Lingyan; Wang, Wenjing (2020). "Safety and Efficacy of Saffron ( Crocus sativus L.) for Treating Mild to Moderate Depression: A Systematic Review and Meta-analysis". The Journal of Nervous and Mental Disease. 208 (4): 269–276. doi: 10.1097/NMD.0000000000001118. PMID 32221179. S2CID 210119504. In late Ptolemaic Egypt, Cleopatra used saffron in her baths so that lovemaking would be more pleasurable. [96] Egyptian healers used saffron as a treatment for all varieties of gastrointestinal ailments. [97] Saffron was also used as a fabric dye in such Levantine cities as Sidon and Tyre in Lebanon. [98] Aulus Cornelius Celsus prescribes saffron in medicines for wounds, cough, colic, and scabies, and in the mithridatium. [99] Western Europe [ edit ] Preserved "Safran", Staatliches Museum für Naturkunde, Karlsruhe, Germany
Monks, Keiron (3 September 2015). "Iran's homegrown treasure: the spice that costs more than gold". CNN . Retrieved 22 January 2016.Russo, E.; Dreher, M. C.; Mathre, M. L. (2003), Women and Cannabis: Medicine, Science, and Sociology (1sted.), Psychology Press, ISBN 978-0-7890-2101-4 Sharaf-Eldin M, Elkholy S, Fernández JA, Junge H, Cheetham R, Guardiola J, Weathers P (August 2008), "Bacillus subtilis FZB24 affects flower quantity and quality of saffron (Crocus sativus)", Planta Medica, 74 (10): 1316–20, doi: 10.1055/s-2008-1081293, PMC 3947403, PMID 18622904 The bitter glucoside picrocrocin is responsible for saffron's pungent flavour. [35] Picrocrocin ( chemical formula: C a b Amanpour, Asghar; Sonmezdag, A. Salih; Kelebek, Hasim; Selli, Serkan (2015). "GC–MS–olfactometric characterization of the most aroma-active components in a representative aromatic extract from Iranian saffron ( Crocus sativus L.)". Food Chemistry. 182: 251–256. doi: 10.1016/j.foodchem.2015.03.005. ISSN 0308-8146. PMID 25842335.